Dr. Rubén Francés Guarinos
Department: CIBERehd-Hospital General Universitario de Alicante
Phone: +34 965 913 928
Current Position: Senior Researcher of the National Health System, Hospital General Universitario de Alicante
Assistant Professor of Immunology, School of Medicine, Universidad Miguel Hernández.
Immunobiology of recurrent bacterial translocation episodes and low-level inflammation in digestive and metabolic diseases. We follow molecular, microbiological and genetic approaches to study the main pathogenic mechanisms of bacterial translocation, from intestinal permeability to bacterial overgrowth and immunological derangements, to identify potential targets to prevent these events and restore intestinal homeostasis both in patients and experimental models.
Gut microbiome composition and development of alternative therapeutic strategies aimed at its modification while preserving the beneficial effects of comensal flora. Biological therapies and their genetically-conditioned interaction with the local and systemic immune responses are also topics of interest for us.
Gómez-Hurtado I, Moratalla A, Moya-Pérez Á, Peiró G, Zapater P, González-Navajas JM, Giménez P, Such J, Sanz Y, Francés R. Role of interleukin 10 in norfloxacin prevention of luminal free endotoxin translocation in mice with cirrhosis. Journal of Hepatol. 2014 Oct;61(4):799-808.
Juanola O, Moratalla A, Gutiérrez A, Sempere L, Zapater P, Giménez P, Almenta I, Peiró G, González-Navajas JM, Such JF, Francés R. Anti-TNF-alpha loss of response is associated with a decreased percentage of FoxP3+ T cells and a variant NOD2 genotype in patients with Crohn's disease. Journal of Gastroenterology. 2014 Dec 11.
Moratalla A, Gómez-Hurtado I, Santacruz A, Moya Á, Peiró G, Zapater P, González-Navajas JM, Giménez P, Such J, Sanz Y, Francés R. Protective effect of Bifidobacterium pseudocatenulatum CECT7765 against induced bacterial antigen translocation in experimental cirrhosis. Liver International. 2014; 34(6):850-8.
Gutiérrez A, Scharl M, Sempere L, Holler E, Zapater P, Almenta I, González-Navajas JM, Such J, Wiest R, Rogler G, Francés R. Genetic susceptibility to increased bacterial translocation influences the response to biological therapy in patients with Crohn's disease. Gut. 2014; 63(2):272-80.
Ortiz S, Zapater P, Estrada JL, Enriquez P, Rey M, Abad A, Such J, Lluis F, Francés R. Bacterial DNA translocation holds increased insulin resistance and systemic inflammatory levels in morbid obese patients. The Journal of Clinical Endocrinology & Metabolism. 2014; 99(7):2575-83.