Department: Departamento de Biología Aplicada. Área de Nutrición y Bromatología

Research Institute: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE)

Phone: (+34) 965 222 165

Email:

Current Position: Associate Professor, Universidad Miguel Hernández (Profesora Titular).

Perfil UMH:

https://www.umh.es/contenido/Universidad/:persona_121847/datos_es.html?marcaTxtBusc=paloma%20alonso%20magdalena

https://idibe.es/es/about/

ORCID: https://orcid.org/0000-0003-1065-5388

Scopus Author ID: 23481028000

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Research Fields

Our main research interest is focused on the identification and study of environmental risk factors, like the endocrine disrupting chemicals, which are key in the etiology of metabolic diseases; with particular interest on their impact on the molecular and cellular processes in the endocrine pancreas. Also, we aim to understand how the pancreatic beta cell adapts to situations of high insulin demand, as occurs in pregnancy, because of its importance in the development of metabolic disorders such as gestational diabetes.

Representative Publications

• Boronat-Belda T, Ferrero H, Al-Abdulla R, Quesada I, Gustafsson JA, Nadal Á, Alonso-Magdalena P*. Bisphenol-A exposure during pregnancy alters pancreatic β-cell division and mass in male mice offspring: A role for ERβ. Food Chem Toxicol. 2020 Nov; 145:111681. doi: 10.1016/j.fct.2020.111681.

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• Audouze K, Sarigiannis D, Alonso-Magdalena P, Brochot C, Casas M, Vrijheid M, Babin PJ, Karakitsios S, Coumoul X, Barouki R. Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders-An Introduction to the OBERON Project. Int J Mol Sci. 2020 Apr 23;21(8): 2988.doi: 10.3390/ijms21082988.

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• Martinez-Pinna J, Marroqui L, Hmadcha A, Lopez-Beas J, Soriano S, Villar-Pazos S, Alonso-Magdalena P, Dos Santos RS, Quesada I, Martin F, Soria B, Gustafsson JÅ, Nadal A. Oestrogen receptor β mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells. Diabetologia. 2019 Sep;62(9):1667-1680. doi: 10.1007/s00125-019-4925-y

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• Tudurí E, Marroqui L, Dos Santos RS, Quesada I, Fuentes E, Alonso-Magdalena P*. Timing of Exposure and Bisphenol-A: Implications for Diabetes Development. Front Endocrinol (Lausanne). 2018 Oct 31;9:648. doi: 10.3389/fendo.2018.00648.

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• Nadal A, Quesada I, Tudurí E, Nogueiras R, Alonso-Magdalena P. Endocrine-disrupting chemicals and the regulation of energy balance. Nat Rev Endocrinol 2017 Sep;13(9):536-546. doi: 10.1038/nrendo.2017.51. 

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• García-Arévalo M, Alonso-Magdalena P#, Servitja JM, Boronat-Belda T, Merino B, Villar-Pazos S, Medina-Gómez G, Novials A, Quesada I, Nadal A. Maternal Exposure to Bisphenol-A During Pregnancy Increases Pancreatic β-Cell Growth During Early Life in Male Mice Offspring. Endocrinology. 2016 Nov;157(11):4158-4171. doi:10.1210/en.2016-1390.

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• Alonso-Magdalena P*, García-Arévalo M, Quesada I, Nadal Á. Bisphenol-A treatment during pregnancy in mice: a new window of susceptibility for the development of diabetes in mothers later in life. Endocrinology. 2015 May;156(5):1659-70. doi: 10.1210/en.2014-1952.

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• García-Arevalo M, Alonso-Magdalena P, Rebelo Dos Santos J, Quesada I, Carneiro EM, Nadal A. Exposure to bisphenol-A during pregnancy partially mimics the effects of a high-fat diet altering glucose homeostasis and gene expression in adult male mice. PLoS One. 2014 Jun 24;9(6):e100214. doi:10.1371/journal.pone.0100214.

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• Alonso-Magdalena P*, Ropero AB, García-Arévalo M, Soriano S, Quesada I,Muhammed SJ, Salehi A, Gustafsson JA, Nadal A. Antidiabetic actions of an estrogen receptor β selective agonist. Diabetes. 2013 Jun;62(6):2015-25. doi:10.2337/db12-1562.