Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche

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Av/ de la Universidad, s/n

03202 Elche, Alicante

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Master Thesis

The Master Thesis consists on a research memory or project in which students can implement the knowledge and skills developed during the course. These projects are carried out under supervision of a tutor and allow each student to acquire practical experience in a research line of interest to them. The Thesis is 30 practical ECTS credits.

At the end of the programme, the students will have to defend their Master Thesis in a viva voice held before the evaluation panel, presenting the content of the project and answering questions from the panel.

Here you will find the regulations regarding the Master Thesis (available in Spanish): 

Specialization Module

Course

2 Compulsory subjects

12 Optional subjects, choice of 6

Research Project or Memory

10.5 Theoretical ECTS | 1.5 Practical ECTS

 

12 Theoretical ECTS  | 6 Practical ECTS

 

30 Practical ECTS

Common Module

Master Thesis

Lines of Research

Each student can choose a line of research of their interest to carry out their Master Thesis under the supervision of a researcher involved in that particular field.

 

Biochemistry

  • Molecular bases of ion channel modulation.

Biocompanies

  • New business models and business strategy in the biotechnology sector..

  • Alliances and networks between companies and research centers. Explanatory factors of their evolution and influence on business and industrial results.

Isabel Devesa

  • Development of active molecules of pharmaceutical and cosmetic use.

Eva Graciá M. Iberogen Environmental Studies

  • Bird Genetics. Creation and validation of a panel of genetic markers for pathogen detection in the order Psittaciformes.

  • Bird Genetics. Creation and validation of a panel of genetic markers for the determination of filiation and/or kinship of the order Psittaciformes.

 

Bioinformatics

  • Search of TRPM8, TRPV1 y TRPA1 thermoreceptor modulators through virtual computer screening.

  • Computational determination of effectors of the TRAAK potasium channel derived from natural compounds.

  • Public computational tools for calculating ADMET properties of compound libraries.

  • Development of multiple molecular coupling platforms for virtual computational screening.

  • Study of membrane-protein interaction by simulation of molecular dynamics of peptides derived from non-structural proteins of enveloped viruses.

  • Search of inhibitors of viral replication by molecular docking.

 

Biomaterials

  • Synthesis and characterization of third generation ceramic materials.

  • Design and obtainment of biomaterials for tissue engineering.

  • Determination of biomaterial bioactivity for applications in odontology and traumatology.

  • Materials for renewable energies.

  • Study and development of biomaterials for 3D printers.

 

Biomolecules

  • Synthesis of fluorescent biomolecules with application as (bio) fluorescent markers for study in cancer therapy.

  • Synthesis of donor-acceptor biomolecules as artificial photosynthetic analogs.

  • Synthesis of biomolecules to act as wine and oil sensors.

  • Synthesis of multifunctional metal-pharmaceuticals for use in cancer diagnosis and therapy.

  • Synthesis of infrared emitting conjugated biomolecules as artificial photosynthetic analogs.

  • Synthesis of biomolecules for renewable energies.

  • Development of solar devices with biomolecules extracted from different varieties of pomegranate.

 

Food Biotechnology

  • Bioactive compounds in juices and beverages.

  • Biotechnology in the integral use of the fruit in its transformation into juice.

  • Fooz enzymology.

  • Biotechnological processes of fermentation in raw materials other than seeds.

Pharmacology

 
  • Study of the absorption of compounds in in vitro models of intestine, placenta and blood-brain barrier.

  • Selection of suitable drugs for the oral route as the most physiological and convenient for patients. How can I find out whether my molecule has a future as an oral drug?

  • Characterization of intestinal absorption. Excipient selection. How can I find out whether my candidate will pass through the intestinal wall and how can I promote its absorption?

  • Comparison of oral pharmaceutical formulations. Formulation strategies. How can I achieve a single daily dose of my drug?

  • Pharmacogenetics applied to pain.

  • Pharmacovigilance, pain and opioids. Cost-effectiveness study.

  • Profile of genetic vulnerability and opioid dependence.

  • Actigraphy for the study of sleep in autism.

  • Relationship between valproic dose level and the interaction with other drugs.

  • Interactions between antihypertensive and antidepressant treatment.

  • Comparative study of treatments with methadone and suboxone

  • Efficacy of methadone and suboxone treatment in opiate-dependent patients.

  • Early stage clinical trials (phase I).

  • Bioequivalence studies.

Photonics

Genetics

 
  • Photography / microscopy with polarized light for the analysis of birefringent biological samples.

  • Development of an automatic photoelectric system for the correction of ocular aberrations.

  • Genetic and molecular characterization of adenosine methylation in Arabidopsis thaliana mRNA.

  • Partenocarpy and incompatibility in Capsella hybrids.

  • Characterization and annotation of transcriptomes of cultivated plants of the genera Passiflora and Allium

  • Genetics, epigenetics and developmental genomics in Arabidopsis.

  • Genetic control of cellular reprogramming during de novo organ formation in plants.

  • Identification of key genes involved in radicular architecture in Solanaceae.

  • Function of the modification of histones in the regulation of the hormonal response during the formation of adventitious roots..

  • Functional analysis of genes involved in silencing pathways mediated by microRNA in Arabidopsis thaliana.

  • Regulation of organelle gene expression and its relation to the development and response to abiotic stress in Arabidopsis thaliana.

  • Characterization of new gene functions involved in mitochondrial translation in Arabidopsis thaliana.

  • Genetic characterization of the RCF3 gene with KH RNA binding motifs (involved in co-transcriptional regulation) during the reproductive development of Arabidopsis thaliana.

 

Biomedical Engineering

  • Development and validation of new non-viral vectors for gene therapy.

  • Visual neuroprostheses and brain plasticity.

  • New therapies for degenerative diseases of the retina based on Optogenetics techniques.

  • Improvement of long-term biocompatibility of neural microelectrodes.

  • Robot-assisted neurorehabilitation.

Protein Engineering

  • Identification of Zika and DENGUE inhibitors. Characterization by biochemical and biophysical techniques.

Immunology

 
  • Antiviral immunology in fish.

  • Immune response of fish erythrocytes to viral infections and DNA vaccines.

  • Innate immune response to viruses in fish. Co-infection and viral persistence models.

 

Molecular Oncology

  • New cancer treatments: development of new treatments for cancer based on natural compounds.

  • Development of new therapies for the treatment of chemoresistant tumors based on nanotechnology and knowledge of the oncogenic signal transduction pathways.

 

Molecular Pathology

  • Prevention of liver cancer in cirrhosis by controlling the sympathetic nervous system mediated stress response.

 

Nanobiotechnology

  • Characterization of pseudo-amyloid fibre formacion through the interaction of proteins with negatively charged surfaces

  • Synthesis, design and characterization of metallic nanoparticles used as transporters of biomolecules and their controlled release.

  • Synthesis, design and characterization of metallic nanoparticles capable of capturing and eliminating contaminants (heavy metals, hypophilic and hydrophobic substances) present in inland waters.

  • Design and development of fluorescent sensors / biosensors with biotechnological applications.

  • Biomolecules and drugs in non-conventional media: biotechnological applications.

  • Fluorescent conjugated polymers as nucleotide detectors of interest.

  • Design and manufacture of polymeric nanomaterials to study the release of drugs in the skin.

  • Development and characterization of multifunctional fluorescent hybrid nanoparticles: Applications in bioimaging and drug transport.

 

New Bioactive Compounds

  • In vitro and in vivo characterization of analgesic compounds.

  • Validation of molecular targets for sensitive skin treatment.

  • Molecular pathogenesis of chronic pain: validation of therapeutic targets.

  • Design and validation of cosmeceuticals for sensitive skin.

  • Development of an in vitro model of innervated skin: biomedical and biotechnological applications.

  • Cosmeceuticals and nutraceutics: detection and bioactivity of new ingredients for cosmetics and nutritional formulations.

  • Natural compounds as agents with potential anti-obesity effects.

  • Capacity of polyphenoles to treat metabolic alterations (oxidative stress and insulin resistance in cellular models and hyperlipidemic mice.

  • Selection of plant extracts and compounds as antimicrobilas for cosmetics, hygiene or medical devices.

  • Characterization of new natural biostimulants (eligible for the Cátedra de Bioestimulantes Naturales award).

 

Nutrition

  • Effectiveness of sport and nutrition in chronic pain.

  • Study of the function of the cells of the Langerhans islets and the mechanisms of regulation of insulin and glucagon secretion. Role of these hormones in glucose homeostasis and in the onset of diabetes or other metabolic problems.

  • Studies of the mechanisms of how diet, in conjunction with exercise, allows the development of preventive and therapeutic strategies in various pathologies, particularly obesity and diabetes.

 

Toxicology

  • Study of biomarkers for exposure and/or effect to pesticides.

  • Alteration of the retinoid system by persistent organic compounds.

  • Evaluation of endocrine disruptors.

  • Study of the interaction of neurotoxic substances with carboxylesterases: identification of neurotoxicity targets.

  • Toxic effects of medication to treat hepatitis C virus.

  • Molecular mechanisms of nanomaterials cytotoxicity.

  • In vitro study of nervous system capacity for toxic activation and in situ detoxification of organophosphorus insecticides.

  • Evaluation of international databases of toxicological information and sources of information in scientific literature.