Dr. María Rose Ponce Molet
Department: Instituto de Bioingeniería
Phone: +34 966 658 503
Current Position: Professor of Genetics, Universidad Miguel Hernández.
One of the mechanisms regulating the expression of eukaryotic genes is mediated by small interfering RNAs (siRNAs), which include microRNAs (miRNAs). To negatively regulate their targets, siRNAs are incorporated into RNA-induced silencing complexes (RISCs), whose main component is a protein of the ARGONAUTE (AGO) family. The miRNA pathway has great biotechnological potential since through its manipulation any endogenous or viral gene can be silenced. We are studying the action and interactions of AGO1 in Arabidopsis thaliana.
Jover-Gil, S., Paz-Ares, J., Micol, J.L., Ponce, M.R.Multi-gene silencing in Arabidopsis: a collection of artificial microRNAs targeting groups of paralogs encoding transcription factors. (2014) Plant Journal 80, 149-160.
Micol-Ponce, R., Aguilera, V., Ponce, M.R. A genetic screen for suppressors of a hypomorphic allele of Arabidopsis ARGONAUTE1. (2014) Scientific Reports 4, 5533.
Wilson-Sánchez, D., Rubio-Díaz, S., Muñoz-Viana, R., Pérez-Pérez, J.M., Jover-Gil, S., Ponce, M.R., Micol, J.L. Leaf phenomics: a systematic reverse genetic screen for Arabidopsis leaf mutants. (2014) Plant Journal 79, 878-891.
Fernández-Nohales, P., Domenech, M.J., Martínez de Alba, A.E., Micol, J.L., Ponce, M.R., Madueño, F. AGO1 controls arabidopsis inflorescence architecture possibly by regulating TFL1 expression. (2014) Annals of Botany 114, 1471-1481.