Department: Departamento Ingeniería. Área de Farmacia y Tecnología Farmacéutica

Phone: +34 965 919 217

Email:

Personal Website: http://marival.edu.umh.es/

Current Position: Professor of Pharmaceutics and Pharmacokinetics, Universidad Miguel Hernández.

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Research Fields

• In vitro models of biological barriers for ADME predictions.

• Biopharmaceutical optimization and Pharmacokinetic evaluation in preclinical models.

• Effects of excipients in oral drug absorption.

• Bioavailability, Bioequivalence. In vivo predictive Dissolution methods for IVIVC.

Representative Publications

• Guillermo Rodríguez-Berna, Víctor Mangas-Sanjuán, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Jose Luis García-Gimenez, María Jose Díaz Cabanas, Marival Bermejo, Avelino Corma. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. European Journal of Medicinal Chemistry 83 (2014) 366-373.

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• Mangas-Sanjuan, Victor; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Bermejo; Marival. Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier. 2013. Molecular Pharmaceutics 10(10): 3822-3831.

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• Samiei N, Mangas-Sanjuan V, González-Álvarez I, Foroutan M, Shafaati A, Zarghi A, Bermejo M. Ion-pair strategy for enabling amifostine oral absorption: Rat in situ and in vivo experiments. 2013. European Journal of Pharmaceutical Sciences. 49(4):499-504.

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• Navarro, C;.González-Álvarez, I; González-Álvarez, M; Manku, M; Merino, M; Casabó, VG.; Bermejo, M. Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. 2011. European Journal of Pharmaceutical Sciences 42(3): 290-299.

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• Prieto P, Hoffmann S, Tirelli V, Tancredi F, González I, Bermejo M, De Angelis I. An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. 2010. Alternatives to Laboratory Animals. 38(5):367-86.