María del Val Bermejo Sanz | master-bioting

Plan de estudios

Trabajo Fin de Máster

Dr. María del Val Bermejo Sanz

Department: Departamento Ingeniería. Área de Farmacia y Tecnología Farmacéutica

Phone: +34 965 919 217

Personal Website: http://marival.edu.umh.es/

Current Position: Professor of Pharmaceutics and Pharmacokinetics, Universidad Miguel Hernández.

Research Fields

In vitro models of biological barriers for ADME predictions.
Biopharmaceutical optimization and Pharmacokinetic evaluation in preclinical models.
Effects of excipients in oral drug absorption.
Bioavailability, Bioequivalence. In vivo predictive Dissolution methods for IVIVC.

Representative Publications

Guillermo Rodríguez-Berna, Víctor Mangas-Sanjuán, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Jose Luis García-Gimenez, María Jose Díaz Cabanas, Marival Bermejo, Avelino Corma. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. European Journal of Medicinal Chemistry 83 (2014) 366-373.

Mangas-Sanjuan, Victor; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Bermejo; Marival. Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier. 2013. Molecular Pharmaceutics 10(10): 3822-3831.

Samiei N, Mangas-Sanjuan V, González-Álvarez I, Foroutan M, Shafaati A, Zarghi A, Bermejo M. Ion-pair strategy for enabling amifostine oral absorption: Rat in situ and in vivo experiments. 2013. European Journal of Pharmaceutical Sciences. 49(4):499-504.

Navarro, C;.González-Álvarez, I; González-Álvarez, M; Manku, M; Merino, M; Casabó, VG.; Bermejo, M. Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. 2011. European Journal of Pharmaceutical Sciences 42(3): 290-299.

Prieto P, Hoffmann S, Tirelli V, Tancredi F, González I, Bermejo M, De Angelis I. An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. 2010. Alternatives to Laboratory Animals. 38(5):367-86.