Department: Departamento Ingeniería. Área de Farmacia y Tecnología Farmacéutica

Phone: +34 965 919 217

Email:

Personal Website: http://marival.edu.umh.es/

Current Position: Professor of Pharmaceutics and Pharmacokinetics, Universidad Miguel Hernández.

​

Research Fields

• In vitro models of biological barriers for ADME predictions.

• Biopharmaceutical optimization and Pharmacokinetic evaluation in preclinical models.

• Effects of excipients in oral drug absorption.

• Bioavailability, Bioequivalence. In vivo predictive Dissolution methods for IVIVC.

Representative Publications

​

• Application of the Gastrointestinal Simulator (GIS) coupled with in silico modeling to measure the impact of Coca Cola® on the luminal and systemic behavior of loratadine (BCS class 2b): Bart Hens *, Marival Bermejo, Patrick Augusjns, Rodrigo Cristofole, Gregory E. Amidon, Gordon L. Amidon. Pharmaceutics. 2020 Jun 18;12(6):566. DOI: 10.3390/pharmaceucs12060566. PMID: 32570975​

​​

• Effect of common excipients on intesnal drug absorpon in Wistar rats. Alejandro Ruiz-Picazo, Marta Gonzalez Alvarez, Isabel Gonzalez-Alvarez*, Marival Bermejo. Mol Pharm. 2020 Jul 6;17(7):2310-2318. DOI: 10.1021/acs.molpharmaceut.0c00023. Epub 2020 Jun 9. PMID: 32469522

​​

• Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients. Alejandro Ruiz-Picazo, Sarin Colón-Useche, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez*, Marival Bermejo, Peter Langguth. Eur J Pharm Biopharm. 2020 Aug;153:168-176. DOI: 10.1016/j.ejpb.2020.06.005. Epub 2020 Jun 17. PMID: 32561342

​​

• A Mechanistic Physiologically-Based Biopharmaceucs Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP. Marival Bermejo, Bart Hens, Joseph Dickens, Deanna Mudie, Paulo Paixão, Yasuhiro Tsume, Kerby Shedden, and Gordon L. Amidon. Pharmaceutics 2020, 12(1), 74; - 17 Jan 2020 . PMID: 31963448 

​​

• Guillermo Rodríguez-Berna, Víctor Mangas-Sanjuán, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Jose Luis García-Gimenez, María Jose Díaz Cabanas, Marival Bermejo, Avelino Corma. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. European Journal of Medicinal Chemistry 83 (2014) 366-373.