Dr. María del Pilar García Morales

Department: Departamento de Bioquímica y Biología Molecular /Área de Biología y Bioquímica Molecular

Phone: +34 966 658 433

Email: garcia@umh.es

Current Position: Fundación para la Investigación Biomédica del Hospital General Universitario de Elche (since 2008)

Research Fields

  • Study of the molecular mechnisms involved in chemorresistance acquisition in cancer.

  • Search of new therapeutical targets for the treatment of chemorresistant tumors.

  • Regulation of expression and activity of ABC proteins.

Representative Publications

  • Castro-Galache M.D., Ferragut, J.A., Barberá V.M., García-Morales, P., González-Ros, J.M., Saceda, M. Apoptosis induction and down-regulation of P-glycoprotein by Trichostatin A in a Daunorubicin-Resistant murine leukemia cell line. 2003. The International Journal of Cancer 104, 579-586

  • García-Morales, P., Gomez-Martinez, A., Carrato, A., Martinez-Lacaci, M.I., Barbera, V.M., Soto, J.L., Carrasco-García, E., Menéndez-Gutierrez, M.P., Castro-Galache, M.D., Ferragut, J.A., Saceda, M. Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines. 2005. Molecular Cancer Therapeutics. 4(8), 1222-1230.

  • García-Morales, P., Hernando, E., Carrasco-Garcia, E., Menéndez-Gutierrez, M.P., Saceda, M., Martinez-Lacaci, I. Cyclin D3 is down regulated by rapamycin in HER2-overexpresing breast cancer cells. 2006. Molecular Cancer Therapeutics. 5 (9), 2172-2181.

  • García-Morales P., Carrasco-García E., Ruiz-Rico P., Martínez-Mira R., Menéndez-Gutiérrez MP., Ferragut JA., Saceda M., Martínez-Lacaci I. Inhibition of Hsp90 function by ansamycin causes downregualtion of cdc2 and cdc25c and G(2)M arrest in glioblastoma cell lines. 2007. Oncogene 26(51), 7185-7193.

  • Gomez-Martinez, A., García-Morales, P., García-Poveda, E., Carrato, A., Castro-Galache, M.D., Soto, J.L., Ferragut, J.A., Saceda, M. Post-transcriptional regulation of P-glycoprotein expresión in colon carcinoma cell lines. 2007. Molecular Cancer Research 5(6), 641-653.