Department: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE) /

Fish erythrocytes in antiviral immunology group

Phone: + 34 966 658 431

Email: 

ResearchGate: Maria del Mar Ortega-Villaizan

Website: https://idibe.es/about/ortega-villaizan-romo-2/

Current Position: Research personnel, Universidad Miguel Hernández.

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Research Fields

• Fish immunology and virology.

• Evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis. 

Representative Publications

• Nombela I, Lopez-Lorigados M, Salvador-Mira ME, Puente-Marin S, Chico V, Ciordia S, Mena MC, Mercado L, Coll J, Perez L, Ortega-Villaizan M. Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets. (2019) Vaccines (Basel) 7(3).
   

• Puente-Marin S, Nombela I, Chico V, Ciordia S, Mena MC, Perez LG, Coll J, Ortega-Villaizan M. Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish. (2019) Vaccines (Basel). 7(3).
   

• Puente-Marin S, Thwaite R, Mercado L, Coll J, Roher N, Ortega-Villaizan M. Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNFα and a G-VHSV Fragment. (2019) Frontiers in Immunology.10:1055.
   

• Chico V, Salvador-Mira ME, Nombela I, Puente-Marin S, Ciordia S, Mena MC, Perez L, Coll J, Guzman F, Encinar JA, Mercado L, Ortega-Villaizan M. IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells. (2019) Frontiers in Immunology.10:613.
   

• Nombela I, Requena-Platek R, Morales-Lange B, Chico V, Puente-Marin S, Ciordia S, Mena MC, Coll J, Perez L, Mercado L, Ortega-Villaizan M. Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers. (2019) Cells. 8(5).
   

• Jung MH, Chico V, Ciordia S, Mena MC, Jung SJ, Ortega-Villaizan M. The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells. (2019) Frontiers in Immunology.10:160.
   

• Puente-Marin S, Nombela I, Chico V, Ciordia S, Mena MC, Coll J, Mercado L, Ortega-Villaizan M. Rainbow Trout Erythrocytes ex vivo Transfection With a DNA Vaccine Encoding VHSV Glycoprotein G Induces an Antiviral Immune Response. (2019) Frontiers in Immunology. 9:2477.
   

• Chico V, Nombela I, Puente-Marín S, Ortega-Villaizan M. Nucleated Red Blood Cells Contribute to the Host Immune Response Against Pathogens, Immune Response Activation and Immunomodulation, Rajeev K. Tyagi and Prakash S. Bisen. (2018) IntechOpen.
   

• I Nombela. M Ortega-Villaizan. Nucleated red blood cells: immune cell mediators of the antiviral response. (2018) PLOS Pathogens. In Press.​

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• S Puente-Marin, I Nombela, S Ciordia, MC Mena, V Chico, J Coll, M Ortega-Villaizan. In silico functional networks identified in fish nucleated red blood cells by means of transcriptomic and proteomic profiling. (2018) Genes. 9 (4), 202

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• V Chico, S Puente-Marin, I Nombela, S Ciordia, MC Mena, B Carracedo, AJ Villena, L Mercado, J Coll, M Ortega Villaizan. Shape-shifted red blood cells: a novel red blood cell stage? (2018) Cells. In Press.

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• Medina-Gali RM, M Ortega-Villaizan, Mercado L, Novoa B, Coll JM, Perez L. Beta-glucan enhances the response to SVCV infection in zebrafish. (2018) Developmental and Comparative Immunology. 7 - 84, pp. 307 - 314.

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• I Nombela, S Puente-Marin, V Chico, AJ Villena, B Carracedo, S Ciordia, MC Mena, L Mercado, L Perez; J Coll, A Estepa, M Ortega-Villaizan. Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus [version 2; referees: 2 approved, 1 approved with reservations].(2017) F1000Research. 6 - 1958.

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• I Nombela; A Carrion; S Puente-Marin; V Chico; L Mercado; L Perez; J Coll; M Ortega-Villaizan. Infectious pancreatic necrosis virus triggers antiviral immune response in rainbow trout red blood cells, despite not being infective [version 2; referees: 2 approved]. (2017) F1000Research. 6 - 1968.

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• MH Jung, J Lee, M Ortega-Villaizan, L Perez, SJ Jung. Protective immunity against Megalocytivirus infection in rock bream (Oplegnathus fasciatus) following CpG ODN administration. (2017) Vaccine. 35 - 30, pp. 3691 - 3699.

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• García-Valtanen P, Martinez-Lopez A, Lopez-Muñoz A, Bello M, Medina-Gali RM,M Ortega-Villaizan, Varela M; Figueras A, Mulero V, Novoa B, Coll JM. Zebrafish lacking adaptive immunity acquire an anti-viral alert state characterized by upregulated gene expression of apoptosis, multi-gene families and interferon-related genes. (2017) Frontiers in Immunology. 8:668.

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