Mª del Mar Ortega-Villaizán Romo | master-bioting

Plan de estudios

Trabajo Fin de Máster

Dr. Mª del Mar Ortega-Villaizán Romo

Department: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE) / Fish erythrocytes in antiviral immunology group

Phone: + 34 966 658 431

ResearchGate: Maria del Mar Ortega-Villaizan

Website: http://ibmc.umh.es/antiviral-immunology.asp

Current Position: Research personnel, Universidad Miguel Hernández.

Research Fields

Fish immunology and virology.
Evaluation of the crosstalk between red and white blood cells in the scenario of fish viral infections and prophylaxis.

Representative Publications

I Nombela. M Ortega-Villaizan. Nucleated red blood cells: immune cell mediators of the antiviral response. (2018) PLOS Pathogens. In Press.

S Puente-Marin, I Nombela, S Ciordia, MC Mena, V Chico, J Coll, M Ortega-Villaizan. In silico functional networks identified in fish nucleated red blood cells by means of transcriptomic and proteomic profiling. (2018) Genes. 9 (4), 202

V Chico, S Puente-Marin, I Nombela, S Ciordia, MC Mena, B Carracedo, AJ Villena, L Mercado, J Coll, M Ortega Villaizan. Shape-shifted red blood cells: a novel red blood cell stage? (2018) Cells. In Press.

Medina-Gali RM, M Ortega-Villaizan, Mercado L, Novoa B, Coll JM, Perez L. Beta-glucan enhances the response to SVCV infection in zebrafish. (2018) Developmental and Comparative Immunology. 7 - 84, pp. 307 - 314.

I Nombela, S Puente-Marin, V Chico, AJ Villena, B Carracedo, S Ciordia, MC Mena, L Mercado, L Perez; J Coll, A Estepa, M Ortega-Villaizan. Identification of diverse defense mechanisms in rainbow trout red blood cells in response to halted replication of VHS virus [version 2; referees: 2 approved, 1 approved with reservations].(2017) F1000Research. 6 - 1958.

I Nombela; A Carrion; S Puente-Marin; V Chico; L Mercado; L Perez; J Coll; M Ortega-Villaizan. Infectious pancreatic necrosis virus triggers antiviral immune response in rainbow trout red blood cells, despite not being infective [version 2; referees: 2 approved]. (2017) F1000Research. 6 - 1968.

MH Jung, J Lee, M Ortega-Villaizan, L Perez, SJ Jung. Protective immunity against Megalocytivirus infection in rock bream (Oplegnathus fasciatus) following CpG ODN administration. (2017) Vaccine. 35 - 30, pp. 3691 - 3699.

García-Valtanen P, Martinez-Lopez A, Lopez-Muñoz A, Bello M, Medina-Gali RM,M Ortega-Villaizan, Varela M; Figueras A, Mulero V, Novoa B, Coll JM. Zebrafish lacking adaptive immunity acquire an anti-viral alert state characterized by upregulated gene expression of apoptosis, multi-gene families and interferon-related genes. (2017) Frontiers in Immunology. 8:668.

Ortega-Villaizan M*, Chico V*, Martinez-Lopez A, Garcia-Valtanen P, Coll JM, Estepa A. Development of new therapeutical/adjuvant molecules by pepscan mapping of autophagy and IFN inducing determinants of rhabdoviral G proteins. (2016) Molecular Immunology. Feb;70:118-24.

García-Valtanen P*, Ortega-Villaizán M*, Martínez-López A, Medina-Gali R, Pérez L, Mackenzie S, Figueras A, Coll JM, Estepa A. Autophagy-inducing peptides from mammalian VSV and fish VHSV rhabdoviral G glycoproteins (G) as models for the development of new therapeutic molecules. (2014) Autophagy,10(9):1666-80.

García-Valtanen P, Martinez-Lopez A,Ortega-Villaizan M, Perez L, Coll JM, Estepa A. In addition to its antiviral and immunomodulatory properties, the zebrafish beta-defensin 2 (zfBD2) is a potent viral DNA vaccine molecular adjuvant. (2014) Antiviral Research. 101, pp. 136 - 147.

Martinez-Lopez A, García-Valtanen P, Ortega-Villaizan M, Chico V, Gomez-Casado E, Coll JM, Estepa A. VHSV G glycoprotein major determinants implicated in triggering the host type I IFN antiviral response as DNA vaccine molecular adjuvants. (2014) Vaccine. 32, pp. 6012 - 6019.

Martinez-Lopez A, García-Valtanen P, Ortega-Villaizan M, Chico V, Medina-Gali RM, Perez L, Coll J, Estepa A. Increasing versatility of the DNA vaccines through modification of the subcellular location of plasmid-encoded antigen expression in the in vivo transfected cells. (2013) PLoS One. 8 – 10.