Dr. Laura Marroquí Esclapez

Department: Physiology

Phone: +34 965 222 962

Email: lmarroqui@umh.es

Twitter: @isletbiologylab

ORCID: 0000-0003-2931-9317

Current Position: Assistant professor (Profesor Ayudante Doctor).

Research Fields

  • We are a research team interested in pancreatic islet function and survival in health and diabetes. Our research aims to understand the molecular differences between alpha and beta cells that allow the former to survive during diabetes development. This knowledge might help us to protect beta cells and, therefore, to either prevent or slow diabetes progression in susceptible individuals.

Representative Publications

  • L.Marroqui; A. A. Perez-Serna; I Babiloni Chust; R. S. Dos Santos. 2021. Type I interferons as key players in pancreatic β-cell dysfunction in type 1 3 diabetes. Int Rev Cell Mol Biol (IF: 4.934; Q1). 2021;359:1-80. DOI: 10.1016/bs.ircmb.2021.02.011.

  • Marroqui L; Martinez-Pinna J; Castellano-Muñoz M; et al; Nadal A. 2020. Bisphenol-S and Bisphenol-F alter mouse pancreatic β-cell ion cannel expression and activity and insulin release through an estrogen receptor ERβ mediated Pathway. Chemosphere (IF: 5.778; Q1). 2021 Feb;265:129051. doi: 10.1016/j.chemosphere.2020.129051.

  • Martinez-Pinna J; Marroqui L; Hmadcha A; et al; Nadal A. 2019. Oestrogen receptor alpha mediates bisphenol-A actions on ion channel expression in mouse pancreatic beta cells. Diabetologia (IF: 7.518; Q1). 2019 Sep;62(9):1667-1680. doi: 10.1007/s00125-019-4925-y. 

  • Marroqui L, Tudurí E, Alonso-Magdalena P, Quesada I, Nadal Á, Dos Santos RS. Mitochondria as target of endocrine-disrupting chemicals: implications for type 2 diabetes. J Endocrinol (IF: 4.041; Q1). 2018 Nov 1;239(2):R27-R45. doi: 10.1530/JOE-18-0362.​

  • Marroqui, L.; Dos Santos, RS.; Op de Beeck, A.; Coomans de Brachène, A.; Marselli, L.; Marchetti, P.; Eizirik, DL. 2017. Interferon-alpha mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes. Diabetologia (IF: 7.518; Q1). 2017 Apr;60(4):656-667. doi: 10.1007/s00125-016-4201-3. 

  • Marroqui, L.; Masini, M.; Merino, B.; et al; Eizirik, DL. 2015. Pancreatic alpha Cells are Resistant to Metabolic Stress-induced Apoptosis in Type 2 Diabetes. EBioMedicine (IF: 5.736; Q1). 2015 Mar 17;2(5):378-85. doi: 10.1016/j.ebiom.2015.03.012.

  • Marroqui, L. (AC); Dos Santos, RS.; Fløyel, T.; et al; Eizirik, DL.  2015. TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic beta-Cells. Diabetes (IF: 7.72; Q1). 2015 Nov;64(11):3808-17. doi: 10.2337/db15-0362.

  • Marroqui, L. *; Lopes, M. *; dos Santos, RS. *; et al; Eizirik, DL. 2015. Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic alpha and beta cells. Elife (IF: 7.08; Q1). 2015 Jun 10;4:e06990. doi: 10.7554/eLife.06990.