Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche

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Av/ de la Universidad, s/n

03202 Elche, Alicante

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© 2017  Universidad Miguel Hernández. Diseño Web: C. Sala Ripoll 

Dr. José Villalaín Boullón

Department: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE) / Viral Membrane Proteins Group

Phone: +34 966 658 762

Email: jvillalain@umh.es

Current Position: Professor of Biochemistry and Molecular Biology.

Research Fields

  • The study of the structure and interaction of DENV virus derived peptide libraries comprising the viral structural and non-structural proteins with model biomembranes, aiming to identify their molecular mechanism and biological function. Screening of peptide libraries to identify membranotropic determinants, characterize the interactions in structural terms, study the structure of the membranotropic segments, and make a detailed study of the interaction, modulation and structure of these peptide segments with membranes and living cells.

  • Develop molecular dynamics bioinformatic tools to study the interaction of viral proteins with biomembranes to find new antivirals and therapeutic targets to develop new leading compounds useful for improved combined therapies.

Representative Publications

  • Membrane interacting regions of Dengue virus NS2A protein. Nemésio H, Villalaín J. (2014) Journal of Physical Chemistry B. Aug 28;118(34):10142-55.

  • Membranotropic regions of the dengue virus prM protein. Nemésio H, Villalaín J. (2014) Biochemistry Aug 19;53(32):5280-9.

  • N-terminal AH2 segment of protein NS4B from hepatitis C virus. Binding to and interaction with model biomembranes. Palomares-Jerez MF, Nemesio H, Franquelim HG, Castanho MA, Villalaín J. (2013) Biochimica et Biophysica Acta. Aug;1828(8):1938-52.

  • The membrane spanning domains of protein NS4B from hepatitis C virus. Palomares-Jerez F, Nemesio H, Villalaín J. (2012) Biochimica et Biophysica Acta. 2012 Dec;1818(12):2958-66.

  • Interaction with membranes of the full C-terminal domain of protein NS4B from hepatitis C virus. Palomares-Jerez MF, Nemesio H, Villalaín J. (2012) Biochimica et Biophysica Acta. Nov;1818(11):2536-49.