Dr. Isabel González Álvarez

Department: Departamento Ingeniería. Área de Farmacia y Tecnología Farmacéutica

Phone: +34 965 919 217

Email: isabel.gonzalez@goumh.umh.es

Current Position: Prof. Contratado Doctor of Pharmaceutics and Pharmacokinetics, Universidad Miguel Hernández.

Research Fields

  • In vitro models of biological barriers for ADME predictions.

  • Biopharmaceutical optimization and Pharmacokinetic evaluation in preclinical models.

  • Excipients effects in oral drug absorption.

  • Bioavailability, Bioequivalence. In vivo predictive Dissolution methods for IVIVC.

Representative Publications

  • Lozoya-Agullo I, Zur M, Wolk O, Beig A, González-Álvarez I, González-Álvarez M, Merino-Sanjuán M, Bermejo M, Dahan A. In-situ intestinal rat perfusions for human Fabs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches. International Journal of Pharmaceutics. 2015. 480(1-2):1-7.

  • Mangas-Sanjuan V, González-Álvarez I, González-Álvarez M, Casabó VG, Bermejo M. Modified nonsink equation for permeability estimation in cell monolayers: comparison with standard methods. 2014. Mol. Pharm. 11(5):1403-14.

  • Guillermo Rodríguez-Berna, Víctor Mangas-Sanjuán, Marta Gonzalez-Alvarez, Isabel Gonzalez-Alvarez, Jose Luis García-Gimenez, María Jose Díaz Cabanas, Marival Bermejo, Avelino Corma. A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. 2014. European Journal of Medicinal Chemistry 83:366-373.

  • Mangas-Sanjuan, Victor; Gonzalez-Alvarez, Isabel; Gonzalez-Alvarez, Marta; Bermejo; Marival. Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier. 2013. Molecular Pharmaceutics 10(10): 3822-3831.

  • Samiei N, Mangas-Sanjuan V, González-Álvarez I, Foroutan M, Shafaati A, Zarghi A, Bermejo M Source. Ion-pair strategy for enabling amifostine oral absorption: Rat in situ and in vivo experiments. European Journal of Pharmaceutical Sciences. 2013. 49(4):499-504.

  • Navarro, C; González-Álvarez, I; González-Álvarez, M; Manku, M; Merino, M; Casabó,VG; Bermejo, M. Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model. European Journal of Pharmaceutical Sciences. 2011. 42(3):290-9.

  • Prieto P, Hoffmann S, Tirelli V, Tancredi F, González I, Bermejo M, De Angelis I. An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. Alternatives to laboratory Animals. 2010. 38(5):367-86.