Dr. Cristina Ripoll Orts

Research Fields

Department: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE)

Phone: +34 966 652 009

Email: ripollcr@umh.es

ResearcherID: L-4079-2014

Current Position: Professor of Physiology, Universidad Miguel Hernández.

  • Role of endocrine disruptors, particularly Bisphenol-A, in the etiology of diabetes: we study how exposure to EDCs across lifespan affects insulin sensitivity and the function of the endocrine pancreas. Particularly, we have interest in how endocrine disruptor´s exposure during pregnancy affects offspring glucose metabolism later in life.

  • Role of estrogen receptors ERα, ERβ and GPER1 in the physiology of the islet of Langerhans: how estrogen shape the plasticity of the endocrine pancreas during the adaptation to pregnancy and obesity.

  • Mechanisms and signal transduction pathways that regulate the secretion and function of pancreatic alpha, beta and delta-cells, both at cellular and molecular level. We also study systemic conditions associated to diabetes and obesity, such as hyperglycemia or excess of fatty acids, that lead to dysfunction of pancreatic cells or compromise their survival.

Representative Publications

  • Alonso-Magdalena P, Ropero AB, Soriano S, García-Arévalo M, Ripoll C, Fuentes E, Quesada I, Nadal A. Bisphenol-A acts as a potent estrogen via non-classical estrogen triggered pathways. (2012) Molecular Cell Endocrinology, 355(2):201-7.

  • Marroquí L, Gonzalez A, Ñeco P, Caballero-Garrido E, Vieira E, Ripoll C, Nadal A, Quesada I. Role of leptin in the pancreatic beta-cell: effects and signalling pathways. Journal of Molecular Endocrinology, 49(1):R9-17.

  • Soriano S, Ropero AB, Alonso-Magdalena P, Ripoll C, Quesada I, Gassner B, Kuhn M, Gustafsson JA and Nadal A. Rapid regulation of KATP channel activity by 17beta-estradiol in pancreatic beta-cells involves the estrogen receptor beta and the atrial natriuretic peptide receptor. (2009) Molecular Endocrinology 23: 1973-1982.

  • Quesada I, Tuduri E, Ripoll C, Nadal A. Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes. (2008) Journal of Endocrinology. 199: 5–19.

  • Alonso-Magdalena P., Morimoto S, Ripoll C., Fuentes E. and Nadal A.The estrogenic effect of bisphenol-A disrupt pancreatic beta-cell function in vivo and induces insulin resistance. (2006) Environmental Health Perspectives 114:106-112.

Patents

  • B. Soria, A. Nadal, C. Ripoll, J.M. Rovira, E. Andreu, O. Laribi y T. León-Quinto
    Utilización del 17beta-estradiol, sus análogos y derivados en el tratamiento de la diabetes mellitus y sus manifestaciones. N. DE REGISTRO: P9800625. AÑO: 24 de marzo 1998. ENTIDAD TITULAR: Universidad Miguel Hernández. PAISES: España.

Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche

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Av/ de la Universidad, s/n

03202 Elche, Alicante

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