Dr. Asia Fernández Carvajal

Department: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE)

Phone: +34 966 65 84 54

Email: asia.fernandez@umh.es

Current Position: Professor of Biochemistry and Molecular Biology, Universidad Miguel Hernandez.

Research Fields

  • High throughput screening.

  • Discovery and development of anti-nociceptive drugs.

  • Structure-function studies on ion channels.

Representative Publications

  • Serafini, M.; Griglio, A.; Aprile, S.; Seiti, F.; Travelli, C.; Pattarino, F.; Grosa, G.; Sorba, G.; Genazzani, A.; Gonzalez-Rodriguez, S; Butron, L.; Devesa, Il; Fernández-Carvajal, A.; Pirali, T. and Ferrer-Montiel, A. (2018). Targeting TRPV1 softly: the discovery of Passerini adducts as a topical treatment for inflammatory skin disorders. Journal of Medicinal Chemistry

  • B. Balsera, J. Mulet, S. Sala, F. Sala,  R. Torre Martinez,  S. González-Rodríguez, A. Plata, L. Naesens, A. Fernández-Carvajal, A. Ferrer-Montiel, M. Criado, M.J. Pérez de Vega and  R. González-Muñiz. (2018). Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of α7 nicotinic receptors with analgesic activity. European Journal of Medicinal Chemistry. 143: 157-165.

  • R. Torre-Martínez, M.A. Bonache, P.J. LLabrés, B. Balsera, A Fernández-Carvajal, G. Fernández-Ballester, A. Ferrer-Montiel, M.J. Pérez de Vega, R. González-Muñiz (2017). Synthesis, high-throughput screening and pharmacological characterization of β-lactam derivatives as TRPM8 antagonists. Scientific reports. 7(1):10766-10779.

  • E. Montoya; M.L. Renart, A.M. Giudici; J.A. Poveda; A.M. Fernandez, A. Morales and J.M. Gonzalez-Ros (2017). Differential binding of monovalent cations to KcsA: Deciphering the mechanisms of potassium channel selectivity. Biochim Biophys Acta. 1859(5):779-788.

  • A. Bertaminoa, C. Ostacolo, P. Ambrosino, S. Musella, V. Di Sarno, T. Ciaglia, M.V. Soldovieri, N. Iraci, A. Fernandez-Carvajal, R. A. Ferrer-Montiel, R. Gonzalez Muñiz, E. Novellino, M. Taglialatela, P. Campiglia, I. Gomez-Monterrey. (2016) Tryptamine-based derivatives as Transient Receptor Potential Melastatin type-8 (TRPM8) channel modulators. Journal of Medicinal Chemistry 59(5):2179-91.

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Patents and Available Technologies

  • Fernández-Carvajal A, García-Martínez C, Belmonte C, Van Den Nest W, Carreño C., Ferrer-Montiel A. Compounds which can block the responses to chemical substances or thermal stimuli or mediators of inflammation of nociceptors, production method thereof and compositions containing same.  ES2195787 B1 (granted on 01/06/2005); WO03/097670; EP1506970 A1; US7183430 B2 (granted on 27/02/2003); AU2003/231331; CA2486342 A1; JP2006/502975 ; MX PA/a/04011502.

  • Antonio Ferrer Montiel, Asia Fernández Carvajal, Carolina García Martínez, Carlos Belmonte Martínez, Wim van den Nest,  Cristina Carreño Serraima. New bis-N-(halophenethyl)-glycyl-glycine derivatives, useful as analgesic medicaments, especially for treating inflammatory or neuropathic pain, or in cosmetic compositions. WO2003097670-A; WO2003097670-A1; ES2195787-A1; AU2003231331-A1; EP1506970-A1; KR2005007406-A; ES2195787-B1; US2005130907-A1; JP2006502975-W; US7183430-B2.

  • Antonio Ferrer Montiel, Asia Fernández-Carvajal, Gregorio Fernandez Ballester, José Manuel González Ros, Carlos Belmonte Martínez, Félix Viana, Ana Gomis, Rosa María Planells-Cases, Miquel Vidal, Jordi Bujons, Angel Messeguer. Compuestos moduladores de receptores TRP y sus usos. WO2012/136873 A2.

  • Carlos Belmonte Martínez,  Juana Gallar Martinez , Antonio Ferrer Montiel, Asia Fernández Carvajal,  Felix Viana de la Iglesia. Composición farmacéutica para el tratamiento del ojo seco. Pharmaceutical composition for the treatment of the dry ice. WO2012/032209 A2 EP2614860A2, EP2614860A4, US20130245231,  WO2012032209A3

Company Agreements

  • Antalgenics

  • BCN Peptides

  • DiverDrugs

Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche

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Av/ de la Universidad, s/n

03202 Elche, Alicante

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