Dr. Ángel Nadal Navajas

Department: Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche (IDiBE)

Phone: +34 965 222 002

Email: nadal@umh.es

Researcher ID: G-6721-2014

Current Position: Professor of Physiology, Universidad Miguel Hernández.

Research Fields

We work to understand the role that estrogen receptors ERα, ERβ and GPER1 have in the physiology of the islet of Langerhans. This will give light on how estrogens influence the plasticity of the endocrine pancreas during the adaptation to pregnancy and obesity. We are interested in the role that endocrine disruptors, particularly those with estrogenic activity, have in the etiology of Diabetes.

Representative Publications

  • García-Arevalo M, Alonso-Magdalena P, Rebelo Dos Santos J, Quesada I, Carneiro EM, Nadal AExposure to Bisphenol-A during Pregnancy Partially Mimics the Effects of a High-Fat Diet Altering Glucose Homeostasis and Gene Expression in Adult Male Mice. (2014) Plos One. 9: e100214.

  • Alonso-Magdalena P, Ropero AB, Garcia-Arevalo M, Soriano S, Quesada I, Muhammed SJ, Salehi A, Gustafsson JA, Nadal A. Antidiabetic actions of an ERβ selective agonist. (2013) Diabetes. 62:2015-2025.

  • Soriano S, Alonso-Magdalena P, García-Arévalo M, Novials A, Muhammed SJ, Salehi A, Gustafsson JA, Quesada I., Nadal ARapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor beta. (2012) PLOS One. 7 (2): e31109.

  • Alonso-Magdalena P, Quesada I, Nadal A. Endocrine disruptors in the etiology of type 2 diabetes mellitus. (2011) Nature Reviews Endocrinology. 7:346-353.

  • Alonso-Magdalena P, Vieira E, Soriano S, Menes L, Burks D, Quesada I, Nadal ABisphenol-A Exposure during Pregnancy Disrupts Glucose Homeostasis in Mothers and Adult Male Offspring. (2010) Environmental Health Perspectives. 118: 1243-1250.

Patents and Available Technologies

B. Soria, A. Nadal, C. Ripoll, J.M. Rovira, E. Andreu, O. Laribi y T. León-Quinto. Utilización del 17beta-estradiol, sus análogos y derivados en el tratamiento de la diabetes mellitus y sus manifestaciones. N. DE REGISTRO: P9800625. AÑO: 24 de marzo 1998. ENTIDAD TITULAR: Universidad Miguel Hernández. PAISES: España